Description

3-Pyridinecarbonitrile, 6-(Difluoromethyl)-5-Methyl- is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core with difluoromethyl and nitrile functional groups. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated heterocycles into their molecular designs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides where the difluoromethyl group can improve lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Potential monomer or additive for creating functional polymers and advanced materials with specific electronic properties.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	3-Pyridinecarbonitrile, 6-(Difluoromethyl)-5-Methyl-
CAS No.	1805305-30-9
Molecular Formula	C8H6F2N2
Molecular Weight	168.15 g/mol
Synonyms	6-(Difluoromethyl)-5-methylnicotinonitrile; 5-Methyl-6-(difluoromethyl)pyridine-3-carbonitrile; 6-(Difluoromethyl)-5-methyl-3-cyanopyridine; 3-Cyano-6-(difluoromethyl)-5-methylpyridine; 5-Methyl-6-(difluoromethyl)-3-pyridinecarbonitrile; Nicotinonitrile, 6-(difluoromethyl)-5-methyl-; 1805305-30-9
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonitrile, 6-(Difluoromethyl)-5-Methyl- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and process development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality commitment supports compliance with relevant ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.