Description

6-Chloro-2-(difluoromethyl)-3-fluoropyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and a difluoromethyl group, makes it an indispensable intermediate for creating novel compounds with tailored properties. This product is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialty chemicals, liquid crystals, and advanced polymers with specific electronic or surface properties.
• Chemical Biology Probes: Employed in the creation of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it a versatile substrate for various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex heterocyclic systems.

Basic Information

Product Name	6-Chloro-2-(difluoromethyl)-3-fluoropyridine
CAS No.	1805304-78-2
Molecular Formula	C6H3ClF3N
Molecular Weight	181.54 g/mol
Synonyms	2-(Difluoromethyl)-6-chloro-3-fluoropyridine; 3-Fluoro-6-chloro-2-(difluoromethyl)pyridine; 6-Chloro-3-fluoro-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-3-fluoro-6-chloropyridine; Pyridine, 6-chloro-2-(difluoromethyl)-3-fluoro-; 1805304-78-2
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2-(difluoromethyl)-3-fluoropyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and guarantee high purity and batch-to-batch consistency to meet the stringent requirements of research and scale-up activities. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.