Description

2,4-Dichloro-6-(Difluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring reactive chlorine and difluoromethyl groups, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluoromethyl group.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to create complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying the introduction and effects of fluorine atoms in medicinal and agricultural chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine scaffolds.

Basic Information

Product Name	2,4-Dichloro-6-(Difluoromethyl)Pyridine
CAS No.	1805252-95-2
Molecular Formula	C6H3Cl2F2N
Molecular Weight	197.99 g/mol
Synonyms	6-(Difluoromethyl)-2,4-dichloropyridine; 2,4-Dichloro-6-difluoromethylpyridine; 2,4-Dichloro-6-(difluoromethyl)pyridine; Pyridine, 2,4-dichloro-6-(difluoromethyl)-; 1805252-95-2
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloro-6-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its reactivity profile, it is recommended to handle and store this material under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.