Description

Methyl 2-Bromo-3,5-Difluorobenzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which facilitates selective cross-coupling reactions and further functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved pesticidal activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct biaryl and complex heterocyclic systems.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated benzoate derivatives.

Basic Information

Product Name	Methyl 2-Bromo-3,5-Difluorobenzoate
CAS No.	1805023-66-8
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-3,5-difluorobenzoic acid methyl ester; Methyl 2-bromo-3,5-difluorobenzoate; Benzoic acid, 2-bromo-3,5-difluoro-, methyl ester; 3,5-Difluoro-2-bromobenzoic acid methyl ester; Methyl 3,5-difluoro-2-bromobenzoate
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Bromo-3,5-Difluorobenzoate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry best practices for fine chemical intermediates. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.