Description

5-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid Methyl Ester is a high-value trifluoromethylated pyrimidine derivative, a key building block prized for its ability to impart desirable metabolic stability and lipophilicity to target molecules. This compound is essential for research and development in advanced organic synthesis, particularly in the creation of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of drug candidates, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronic materials and liquid crystals.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	5-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid Methyl Ester
CAS No.	1803862-44-3
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	Methyl 5-(trifluoromethyl)pyrimidine-4-carboxylate; 4-Pyrimidinecarboxylic acid, 5-(trifluoromethyl)-, methyl ester; 5-Trifluoromethyl-4-pyrimidinecarboxylic acid methyl ester; Methyl 5-trifluoromethylpyrimidine-4-carboxylate; 5-(Trifluoromethyl)pyrimidine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.