Description

Methyltetrazine-Peg4-Azide is a heterobifunctional crosslinking reagent engineered for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, bioorthogonal ligation strategies to create stable, functionalized biomolecules and materials. It is primarily utilized by professionals in pharmaceutical R&D, biotech, and advanced materials science for applications such as antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Enables the attachment of fluorophores, biotin, or other probes via bioorthogonal tetrazine ligation with trans-cyclooctene (TCO) or strained alkynes.
• Surface Functionalization: Used to modify nanoparticles, polymers, and diagnostic assay surfaces with azide groups for subsequent click chemistry reactions.
• Polymer Chemistry: Acts as a functional monomer or crosslinker in the synthesis of smart, responsive hydrogels and biomaterials.
• Chemical Biology Probes: Facilitates the creation of activity-based probes for studying enzyme function and cellular processes.
• Diagnostic Reagent Synthesis: Integral in developing sensitive and specific reagents for immunoassays and molecular imaging.

Basic Information

Product Name	Methyltetrazine-Peg4-Azide
CAS No.	1802908-04-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	m-Tetrazine-PEG4-Azide; Methyltetrazine-PEG4-N3; 3-Methyl-1,2,4,5-tetrazine-PEG4-azide; Azido-PEG4-methyltetrazine; Methyl-Tz-PEG4-Azide; Tetrazine-PEG4-N3; 1,2,4,5-Tetrazine-PEG4-azide derivative; Heterobifunctional PEG linker with tetrazine and azide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Methyltetrazine-Peg4-Azide is characterized using advanced analytical techniques to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), functional group integrity, and solvent content are available upon request. We adhere to strict quality management protocols to ensure batch-to-batch consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid or oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Functional Group Integrity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.