Description

Bis-Sulfone-Peg3-Azide is a specialized heterobifunctional crosslinker featuring a sulfone group and a terminal azide, connected by a triethylene glycol (PEG3) spacer. This compound is engineered to enable highly efficient and selective bioconjugation strategies, particularly in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics. It is an essential research and production reagent for pharmaceutical companies, biotech firms, and academic institutions engaged in advanced drug discovery and bioconjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical component for constructing stable, cleavable linkers between monoclonal antibodies and potent cytotoxic payloads.
• Bioconjugation & Protein Labeling: Facilitates site-specific modification of proteins, peptides, and antibodies via click chemistry (e.g., copper-catalyzed or strain-promoted azide-alkyne cycloaddition).
• Polymer & Biomaterial Functionalization: Used to introduce reactive azide groups into polymers, hydrogels, and surfaces for subsequent bio-orthogonal coupling.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and target identification.
• Diagnostic Reagent Synthesis: A key intermediate in the production of diagnostic imaging agents and contrast media.
• Small Molecule Prodrug Development: Enables the creation of targeted prodrugs with controlled release mechanisms.

Basic Information

Product Name	Bis-Sulfone-Peg3-Azide
CAS No.	1802908-01-5
Molecular Formula	C15H28N4O8S2
Molecular Weight	456.53 g/mol
Synonyms	1,11-Bis(methylsulfonyl)-3,6,9-trioxa-2,10-diazaundecane-2,10-diyl diazide; PEG3-Bis-Sulfone-Azide; Azido-PEG3-Bis-Sulfone; Heterobifunctional PEG Crosslinker, Sulfone-PEG3-N3; 2,2'-(2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(ethane-2,1-diyl) bis(methylsulfone) azide derivative; Bis-Sulfone PEG Azide; N3-PEG3-Bis-Sulfone
EINECS	Contact for details

Quality Control

Every batch of Bis-Sulfone-Peg3-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are suitable for research and GMP-grade applications. Certificates of Analysis (COA) detailing purity, identity confirmation (NMR, MS), and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. This material is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere for critical applications.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.