Description

Dde Biotin-Peg4-Azide is a multifunctional chemical reagent designed for advanced bioconjugation and click chemistry applications. This compound integrates a cleavable Dde protecting group, a biotin tag for affinity purification, a tetraethylene glycol spacer for improved solubility, and an azide moiety for strain-promoted azide-alkyne cycloaddition (SPAAC). It is essential for researchers and developers in life sciences and pharmaceutical R&D who require precise, multi-step labeling and purification strategies for proteins, antibodies, and other biomolecules.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of proteins, antibodies, and peptides via SPAAC click chemistry.
• Affinity Purification Probes: Creation of biotinylated probes for streptavidin/avidin-based pull-down assays and purification.
• Chemical Biology Research: Tool compound for studying protein-protein interactions, cellular trafficking, and post-translational modifications.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the controlled assembly of drug-linker constructs with cleavable linkers.
• Diagnostic Reagent Synthesis: Building blocks for immunoassays, biosensors, and molecular imaging agents.
• Material Surface Functionalization: Modification of nanoparticles, polymers, and biosensor surfaces with bioactive molecules.

Basic Information

Product Name	Dde Biotin-Peg4-Azide
CAS No.	1802907-93-2
Molecular Formula	C₃₈H₆₀N₁₀O₁₀S
Molecular Weight	861.02 g/mol
Synonyms	1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-[2-[2-[2-[2-[5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 3-azidopropylcarbamate; Dde Biotin-PEG4-Azide; Biotin-PEG4-Azide Dde; N-(Azido-PEG4)-N'-Biotin-PEG4-Dde; Azide-PEG4-Biotin Dde; Dde Protected Biotin-PEG4-Azide; Biotinylated PEG Azide with Dde; Cleavable Biotin-PEG4-N₃
EINECS	Contact for details

Quality Control

Our Dde Biotin-Peg4-Azide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional validation in conjugation assays. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Functional Test (Conjugation)	≥90% Yield

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.