Description

(5R,9S)-9-Amino-21-(Difluoromethyl)-5-Methyl-21H-3-Aza-1(4,2)-Pyridina-2(5,4)-Pyrazolacyclonaphan-4-One is a high-purity, complex heterocyclic compound featuring a unique fused ring system with amino and difluoromethyl functional groups. This specialized structure makes it a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of drug candidates.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential new chemical entities (NCEs).
• Biochemical Probe Synthesis: Utilized to create labeled or modified compounds for investigating biological pathways and target engagement.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global biopharma industry.

Basic Information

Product Name	(5R,9S)-9-Amino-21-(Difluoromethyl)-5-Methyl-21H-3-Aza-1(4,2)-Pyridina-2(5,4)-Pyrazolacyclonaphan-4-One
CAS No.	1802431-24-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9-Amino-21-(difluoromethyl)-5-methyl-21H-3-aza-1(4,2)-pyridina-2(5,4)-pyrazolacyclonaphan-4-one; (5R,9S)-9-Amino-21-(difluoromethyl)-5-methyl-21H-3-aza-1(4,2)pyridina-2(5,4)pyrazolacyclonaphan-4-one; CAS 1802431-24-8; Difluoromethyl-substituted pyridinopyrazolacyclonaphanone; Advanced pharmaceutical intermediate 1802431-24-8
EINECS	Contact for details

Quality Control

Our (5R,9S)-9-Amino-21-(Difluoromethyl)-5-Methyl-21H-3-Aza-1(4,2)-Pyridina-2(5,4)-Pyrazolacyclonaphan-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is likely light-sensitive and may be hygroscopic; handle and store under an inert atmosphere such as nitrogen or argon for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.