Description

Azido-Peg11-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group at one terminus and a primary amine at the other. This molecular architecture is critical for creating stable, biocompatible conjugates via click chemistry and amide bond formation. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise modification of biomolecules, surfaces, and nanoparticles.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides to drugs, toxins, or fluorophores for creating antibody-drug conjugates (ADCs) and diagnostic probes.
• PEGylation Chemistry: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic profiles of therapeutic peptides and small molecule drugs.
• Surface Functionalization: Modification of nanoparticles, quantum dots, or solid supports for biosensor development, targeted drug delivery systems, and diagnostic platforms.
• Crosslinking Agent: Used as a versatile linker in hydrogel formation, polymer network synthesis, and the fabrication of biomimetic materials.
• Click Chemistry Applications: The azide group readily participates in copper-catalyzed (CuAAC) or strain-promoted (SPAAC) azide-alkyne cycloadditions for efficient, high-yield ligation.
• Lipid-Nanoparticle (LNP) Formulation: Functionalization of lipid components to improve targeting and cellular uptake in mRNA and gene delivery systems.

Basic Information

Product Name	Azido-Peg11-Amine
CAS No.	1800414-71-4
Molecular Formula	C27H55N5O12
Molecular Weight	641.8 g/mol
Synonyms	11-Azido-3,6,9-trioxaundecan-1-amine; Azido-PEG11-amine; N3-PEG11-NH2; α-Azido-ω-amino-triethylene glycol undecaethylene glycol; PEG11 azide amine; Heterobifunctional PEG linker azide-amine; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
EINECS	Contact for details

Quality Control

Every batch of Azido-Peg11-Amine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, functional group integrity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade materials for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Amine Value (Titration)	Contact for details
Azide Content (NMR)	Contact for details
Molecular Weight (GPC)	600 - 680 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.