Description

tert-Butyl 1-Hydroxy-3,9-Diazaspiro[5.5]Undecane-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in areas like central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its complex, three-dimensional spirocyclic structure.
• API Synthesis: Employed in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) for clinical trials.
• Chemical Biology Probe Development: Serves as a core structure for creating tool compounds to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	tert-Butyl 1-Hydroxy-3,9-Diazaspiro[5.5]Undecane-3-Carboxylate
CAS No.	1800219-15-1
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	1-Hydroxy-3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester; tert-Butyl 1-hydroxy-3,9-diazaspiro[5.5]undecane-3-carboxylate; 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1-hydroxy-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 1-hydroxy-3,9-diazaspiro[5.5]undecane-3-carboxylate; 1800219-15-1; BOC-protected diazaspiro amino alcohol
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Hydroxy-3,9-Diazaspiro[5.5]Undecane-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with ICH guidelines and supports development from preclinical stages through to GMP-grade material for advanced clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.