Description

(S)-1-Diethoxyphosphoryl-2-Methylaziridine is a high-purity chiral aziridine derivative, a crucial building block in asymmetric synthesis. This compound matters for its role as a versatile intermediate in the creation of complex, stereochemically defined molecules, enabling the development of novel pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring precise stereocontrol.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific enantiomeric activity is required for efficacy and environmental safety.
• Ligand and Catalyst Development: Serves as a precursor for chiral phosphine and phosphoramidite ligands used in asymmetric catalysis, such as hydrogenation and cross-coupling reactions.
• Peptidomimetic Research: Employed in the construction of aziridine-containing peptidomimetics and constrained amino acid analogs for drug discovery programs.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique chemical functionalities.

Basic Information

Product Name	(S)-1-Diethoxyphosphoryl-2-Methylaziridine
CAS No.	1800100-68-8
Molecular Formula	C7H16NO3P
Molecular Weight	193.18 g/mol
Synonyms	(S)-2-Methyl-1-(diethoxyphosphoryl)aziridine; (S)-1-(Diethoxyphosphoryl)-2-methylaziridine; Diethyl (S)-2-methylaziridin-1-ylphosphonate; (S)-Aziridine, 2-methyl-1-(phosphonoxy)-, diethyl ester; (S)-Diethyl (2-methylaziridin-1-yl)phosphonate; (2S)-2-Methyl-1-(diethoxyphosphoryl)aziridine
EINECS	Contact for details

Quality Control

Our (S)-1-Diethoxyphosphoryl-2-Methylaziridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and purity assessment to meet exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.