Description

5-Azaspiro[2.5]Octane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic amine structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to develop new therapeutic agents with complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Chemistry & Scale-up: Serves as a starting material for the development and optimization of scalable synthetic routes under GMP conditions.
• Bioconjugation & Probe Development: The reactive amine hydrochloride salt can be utilized for labeling and creating chemical probes for biological studies.
• Library Synthesis: Employed in combinatorial and parallel synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Azaspiro[2.5]Octane Hydrochloride
CAS No.	1797157-33-5
Molecular Formula	C7H14ClN
Molecular Weight	147.65 g/mol
Synonyms	5-Azaspiro[2.5]octane, hydrochloride; 5-Azaspiro[2.5]octane HCl; 1-Azaspiro[2.5]octane hydrochloride; Azaspirooctane hydrochloride; Spiro[cyclopropane-1,2'-bicyclo[2.2.2]octan]-1'-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Azaspiro[2.5]Octane Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.