Description

tert-Butyl 5-Amino-2-azaspiro[3.3]heptane-2-carboxylate hydrochloride is a high-purity, protected spirocyclic amine building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, offering a rigid, three-dimensional scaffold that is highly sought after in drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries to create novel active pharmaceutical ingredients (APIs) with improved properties.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in neuroscience and oncology.
• Medicinal Chemistry: Used to introduce the constrained 2-azaspiro[3.3]heptane motif into lead compounds to modulate potency, selectivity, and pharmacokinetic profiles.
• Process Research & Development (PR&D): Serves as a starting material or advanced intermediate in the scale-up and optimization of API synthesis routes.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized in the construction of linkers and warheads due to its spirocyclic structure and amine functionality.
• Chemical Biology Probes: Incorporated into tool compounds for target identification and validation studies within biological systems.
• Academic Research: Employed in synthetic organic chemistry and methodology development for creating complex heterocyclic architectures.

Basic Information

Product Name	tert-Butyl 5-Amino-2-azaspiro[3.3]heptane-2-carboxylate hydrochloride
CAS No.	1788054-91-0
Molecular Formula	C11H21ClN2O2
Molecular Weight	248.75 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester, hydrochloride; 5-Amino-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hydrochloride; tert-Butyl 5-amino-2-azaspiro[3.3]heptane-2-carboxylate HCl; 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-5-amine hydrochloride; Boc-2-azaspiro[3.3]heptan-5-amine hydrochloride; 5-Amino-2-Boc-2-azaspiro[3.3]heptane hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Amino-2-azaspiro[3.3]heptane-2-carboxylate hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.