Description

5'‐Bromo‐1'‐Ethenyl‐1',2'‐ Dihydrospiro[Cyclopropane‐1,3'‐Indole]‐2'‐One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for novel drug candidates. It is primarily sought after by R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of targeted small molecule therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential ligand or linker component in the design of targeted protein degraders.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological processes and protein function.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses to construct intricate molecular architectures.

Basic Information

Product Name	5'‐Bromo‐1'‐Ethenyl‐1',2'‐ Dihydrospiro[Cyclopropane‐1,3'‐Indole]‐2'‐One
CAS No.	1788054-77-2
Molecular Formula	C13H10BrNO
Molecular Weight	276.13 g/mol
Synonyms	5'-Bromo-1'-ethenyl-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one; 5'-Bromo-1'-vinylspiro[cyclopropane-1,3'-indolin]-2'-one; 5'-Bromo-1'-vinyl-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one; 1788054-77-2; Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-bromo-1'-ethenyl-1',2'-dihydro-; 5'-Bromo-1'-vinyl-2,3-dihydrospiro[cyclopropane-1,3'-indol]-2'-one
EINECS	Contact for details

Quality Control

Our 5'‐Bromo‐1'‐Ethenyl‐1',2'‐ Dihydrospiro[Cyclopropane‐1,3'‐Indole]‐2'‐One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.