Description

3,3-Difluoropiperidine-4,4-Diol Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated piperidine diol scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel bioactive molecules, particularly protease inhibitors and other enzyme-targeted therapeutics. It is primarily sought by R&D and process development teams in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially those targeting enzymatic pathways.
• Protease Inhibitor Development: Used in research and production of inhibitors for various proteases, a key class of therapeutic targets.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by introducing a rigid, fluorinated diol moiety into lead compounds.
• Bioconjugation & Probe Synthesis: Serves as a starting material for creating chemical probes and bioconjugates used in biochemical assays and diagnostic research.
• Academic & Institutional Research: Utilized in university and research institute labs for investigating new synthetic methodologies and biological mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects for global clients.

Basic Information

Product Name	3,3-Difluoropiperidine-4,4-Diol Hydrochloride
CAS No.	1788044-01-8
Molecular Formula	C5H8F2NO2·HCl
Molecular Weight	187.58 g/mol (Free base)
Synonyms	4,4-Dihydroxy-3,3-difluoropiperidine hydrochloride; 3,3-Difluoropiperidine-4,4-diol HCl; 4,4-Dihydroxy-3,3-difluoropiperidine HCl salt; 3,3-Difluoro-4,4-piperidinediol hydrochloride; 4,4-Piperidinediol, 3,3-difluoro-, hydrochloride; 3,3-Difluoropiperidine-4,4-diol monohydrochloride
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropiperidine-4,4-Diol Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.