Description

D-Ribofuranose, 4-C-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclopropyl]-3,5-Bis-o-(Phenylmethyl)-, 1,2-Diacetate is a sophisticated, high-purity synthetic intermediate featuring a protected ribofuranose core with strategically positioned silyl ether and benzyl protecting groups. This compound matters as a critical building block for the synthesis of complex nucleoside analogs and modified carbohydrates, enabling advanced research in medicinal chemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel antiviral agents, mRNA therapeutics, and other bioactive molecules where precise sugar moiety manipulation is required.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• ProTide Technology: Serves as a protected sugar component in the synthesis of ProTide prodrugs, which enhance the bioavailability and intracellular delivery of nucleotide therapeutics.
• Oligonucleotide Synthesis: Used in the research and development of modified oligonucleotides, including those for siRNA and antisense applications, where a protected ribose derivative is necessary.
• Carbohydrate Chemistry Research: An essential reagent for academic and industrial labs studying glycosylation reactions, protecting group strategies, and the synthesis of complex glycomimetics.
• Process Chemistry Development: Employed in scaling up routes to active pharmaceutical ingredients (APIs) that contain modified ribose or related sugar structures.
• Labeled Compound Synthesis: Acts as a starting material for introducing isotopic labels (e.g., 13C, 2H) into sugar moieties for metabolic tracing studies or as internal standards.

Basic Information

Product Name	D-Ribofuranose, 4-C-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclopropyl]-3,5-Bis-o-(Phenylmethyl)-, 1,2-Diacetate
CAS No.	1784750-26-0
Molecular Formula	C31H42O7Si
Molecular Weight	554.75 g/mol
Synonyms	1,2-Di-O-acetyl-3,5-di-O-benzyl-4-C-[1-[(tert-butyldimethylsilyl)oxy]cyclopropyl]-D-ribofuranose; 3,5-Di-O-benzyl-4-C-[1-[(tert-butyldimethylsilyl)oxy]cyclopropyl]-1,2-di-O-acetyl-D-ribofuranose; 4-C-[1-[(tert-Butyldimethylsilyl)oxy]cyclopropyl]-3,5-di-O-benzyl-1,2-di-O-acetyl-D-ribofuranose; TBDMS-protected cyclopropyl ribofuranose diacetate; Protected Cyclopropyl Ribose Intermediate; CAS 1784750-26-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profile to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The compound is moisture-sensitive; ensure containers are sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.