Description

7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonan-3-One is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a sophisticated building block for novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of complex therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained spirocyclic scaffold.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Proteolysis Targeting Chimera (PROTAC) Development: Potential application as a linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonan-3-One
CAS No.	1782480-53-8
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	2-Azaspiro[4.4]nonan-3-one, 7-(hydroxymethyl)-; 7-(Hydroxymethyl)-2-azaspiro[4.4]nonan-3-one; 2-Azaspiro[4.4]nonane-3-one, 7-(hydroxymethyl)-; 7-(Hydroxymethyl)-2-azaspiro[4.4]nonane-3-one; 1782480-53-8; 7-Hydroxymethyl-2-azaspiro[4.4]nonan-3-one; Azaspiro Intermediate 1782480-53-8
EINECS	Contact for details

Quality Control

Our 7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonan-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.