Description

2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid CAS NO 1782355-62-7 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amino acid structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry and drug discovery programs. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting various proteases.
• Peptidomimetic Chemistry: Used to construct conformationally constrained peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Library Synthesis for HTS: A valuable reactant for generating diverse compound libraries used in high-throughput screening campaigns.
• Process Chemistry & Scale-Up: Suitable for optimization and scale-up from milligram to kilogram quantities under GMP-like conditions.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid
CAS No.	1782355-62-7
Molecular Formula	C₁₃H₂₁NO₅
Molecular Weight	271.31 g/mol
Synonyms	Boc-5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid; 8-Carboxy-2-(tert-butoxycarbonyl)-5-oxa-2-azaspiro[3.5]nonane; 2-[(2-Methylpropan-2-yl)oxycarbonyl]-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic acid; 5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 8-carboxy-5-oxa-2-azaspiro[3.5]nonane-2-carboxylate; Boc-Spirocyclic Amino Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid is manufactured and tested under strict quality management systems. We ensure compliance with stringent internal specifications, which are aligned with the needs of pharmaceutical development. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to guarantee identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.