Description

2'',3''-Dihydrospiro[Cyclopropane-1,4''(1''H)-Isoquinolin]-1''-One CAS NO 1782267-00-8 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic molecular architecture. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, especially within the central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates with potential neurological or anticancer activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained spirocyclic scaffold.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic compounds in academic and industrial research settings.
• Biochemical Tool Compound: Potential use in developing probes for studying biological pathways and enzyme interactions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	2'',3''-Dihydrospiro[Cyclopropane-1,4''(1''H)-Isoquinolin]-1''-One
CAS No.	1782267-00-8
Molecular Formula	C11H11NO
Molecular Weight	173.21 g/mol
Synonyms	2',3'-Dihydrospiro[cyclopropane-1,4'-isoquinolin]-1'-one; Spiro[cyclopropane-1,4'-isoquinolin]-1'-one, 2',3'-dihydro-; 2,3-Dihydrospiro[cyclopropane-1,4-isoquinolin]-1-one; 1782267-00-8; Spirocyclic isoquinolinone; Dihydrospirocyclopropaneisoquinolinone
EINECS	Contact for details

Quality Control

Our 2'',3''-Dihydrospiro[Cyclopropane-1,4''(1''H)-Isoquinolin]-1''-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.