Description

Methyl 5-Bromo-2-Propan-2-Yloxypyridine-3-Carboxylate CAS NO 1781982-05-5 is a high-purity, synthetically valuable pyridine derivative, specifically designed as a key building block in advanced organic synthesis. Its molecular structure, featuring both a bromo substituent and an isopropoxy group, makes it an essential intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a key precursor in the creation of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Used in the development of organic ligands for catalysis and functional materials due to its modifiable pyridine structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: An ideal starting material for custom synthesis projects and contract research organizations (CROs/CMOs) requiring specific, high-purity intermediates.

Basic Information

Product Name	Methyl 5-Bromo-2-Propan-2-Yloxypyridine-3-Carboxylate
CAS No.	1781982-05-5
Molecular Formula	C10H12BrNO3
Molecular Weight	274.11 g/mol
Synonyms	Methyl 5-bromo-2-isopropoxynicotinate; 5-Bromo-2-isopropoxypyridine-3-carboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 5-bromo-2-(1-methylethoxy)-, methyl ester; 2-Isopropoxy-5-bromonicotinic acid methyl ester; Methyl 5-bromo-2-(propan-2-yloxy)nicotinate; 5-Bromo-2-isopropoxy-3-pyridinecarboxylic acid methyl ester; Methyl 5-bromo-2-(1-methylethoxy)-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Bromo-2-Propan-2-Yloxypyridine-3-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and our quality system is designed to meet the rigorous demands of global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.