Description

4-(tert-Butoxycarbonyl)-4-Azaspiro[2.5]Octane-7-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and protected amine structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in cutting-edge drug discovery and process chemistry.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for synthesizing complex molecules with potential therapeutic activity.
• Pharmaceutical API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs), especially for neurological and oncological targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structural features make it a valuable component in the design of linker molecules for targeted protein degradation platforms.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in novel compound libraries.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog for creating stable peptide-like structures.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing of clinical trial materials.

Basic Information

Product Name	4-(tert-Butoxycarbonyl)-4-Azaspiro[2.5]Octane-7-Carboxylic Acid
CAS No.	1781349-46-9
Molecular Formula	C15H23NO4
Molecular Weight	281.35 g/mol
Synonyms	7-Carboxy-4-azaspiro[2.5]octane-4-carboxylic acid tert-butyl ester; 4-Boc-4-azaspiro[2.5]octane-7-carboxylic acid; tert-Butyl 7-carboxy-4-azaspiro[2.5]octane-4-carboxylate; 4-Azaspiro[2.5]octane-7-carboxylic acid, 4-[(1,1-dimethylethoxy)carbonyl]-; Boc-4-azaspiro[2.5]octane-7-COOH; 4-N-Boc-4-azaspiro[2.5]octane-7-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxycarbonyl)-4-Azaspiro[2.5]Octane-7-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.