Description

1,1-Difluorospiro[2.5]Octan-6-Ol is a high-value, structurally complex fluorinated spirocyclic alcohol. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of novel active molecules. It is primarily utilized by R&D and process chemistry teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate unique fluorinated spiro scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the difluorospiro moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis due to its rigid, three-dimensional structure.
• Material Science: Potential building block for specialty polymers, liquid crystals, or organic electronic materials requiring fluorinated components.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects and library production.

Basic Information

Product Name	1,1-Difluorospiro[2.5]Octan-6-Ol
CAS No.	1781334-37-9
Molecular Formula	C8H12F2O
Molecular Weight	162.18 g/mol
Synonyms	6-Hydroxy-1,1-difluorospiro[2.5]octane; 1,1-Difluoro-6-hydroxy-spiro[2.5]octane; Spiro[2.5]octan-6-ol, 1,1-difluoro-; 1,1-Difluorospirooctan-6-ol; Difluorospirooctanol; DFSO
EINECS	Contact for details

Quality Control

Our 1,1-Difluorospiro[2.5]Octan-6-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support custom purity and packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.