Description

Methyl 2,2-Difluorocyclopentane-1-Carboxylate is a high-value fluorinated cyclopentane derivative, serving as a critical building block in advanced organic synthesis. Its unique difluorocyclopentane core is prized for modulating the physicochemical properties of target molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and novel fluorination methodologies in academic and industrial R&D.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fluorinated fine chemicals and flavors & fragrances.

Basic Information

Product Name	Methyl 2,2-Difluorocyclopentane-1-Carboxylate
CAS No.	1781329-42-7
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	2,2-Difluorocyclopentanecarboxylic Acid Methyl Ester; Methyl 2,2-Difluorocyclopentanecarboxylate; 1-Carbomethoxy-2,2-difluorocyclopentane; Cyclopentanecarboxylic acid, 2,2-difluoro-, methyl ester; Methyl difluorocyclopentanecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluorocyclopentane-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including chromatographic and spectroscopic methods, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.