Description

2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemistry research and development, offering a valuable scaffold for creating novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of new drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used as a privileged scaffold in drug discovery programs to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Agrochemical Synthesis: Employed in the development of new generation pesticides and herbicides, where the difluoro moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1)
CAS No.	1781297-18-4
Molecular Formula	C9H16ClF2N
Molecular Weight	211.68 g/mol
Synonyms	8,8-Difluoro-2-azaspiro[4.5]decane hydrochloride; 2-Azaspiro[4.5]decane, 8,8-difluoro-, hydrochloride; 8,8-Difluoro-2-azaspiro[4.5]decane HCl; 8,8-Difluoro-2-azaspiro[4.5]decane monohydrochloride; 2-Azaspiro[4.5]decane-8,8-difluoro hydrochloride; 8,8-Difluoro-2-azaspiro[4.5]decane hydrochloride (1:1); 8,8-Difluoro-2-azaspiro[4.5]decan-2-ium chloride
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.