Description

Ethyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride is a high-purity fluorinated pyrrolidine derivative, serving as a critical building block in modern pharmaceutical and agrochemical research. Its value lies in the unique reactivity and metabolic stability imparted by the difluorinated pyrrolidine scaffold, making it indispensable for the synthesis of novel bioactive compounds. This advanced intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for developing new drug candidates and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Building block for novel herbicides, fungicides, and insecticides leveraging fluorine's bioactivity.
• Chemical Biology: Used in the synthesis of molecular probes and labeled compounds for studying biological pathways.
• Peptidomimetics: Core structure for designing conformationally constrained peptide analogs with enhanced stability.
• Material Science: Potential precursor for specialty polymers and advanced materials with tailored properties.
• Process Chemistry: Scalable intermediate for the GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ethyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride
CAS No.	1780567-10-3
Molecular Formula	C7H12ClF2NO2
Molecular Weight	215.63 g/mol
Synonyms	Ethyl 4,4-difluoro-3-pyrrolidinecarboxylate hydrochloride; 3-Carbethoxy-4,4-difluoropyrrolidine hydrochloride; 4,4-Difluoropyrrolidine-3-carboxylic acid ethyl ester hydrochloride; 1-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 4,4-difluoro-, ethyl ester, hydrochloride; Ethyl 4,4-difluoro-1-azabicyclo[3.1.0]hexane-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.