Description

tert-Butyl 8-Hydroxy-5-Oxa-2-Azaspiro[3.5]Nonane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and oxazolidinone-like structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-infective drugs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to build molecular complexity and introduce chiral centers.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for constructing complex spirocyclic scaffolds found in modern pharmaceuticals.
• CNS Drug Development: Used in the research and production of potential therapeutics for neurological disorders.
• Anti-infective Agent Research: Employed in the synthesis of novel antibiotic and antiviral compounds.
• Chiral Synthesis: Provides a stereodefined template for introducing chirality into target molecules, essential for drug efficacy.
• Process Chemistry & Scale-Up: Suitable for optimization from laboratory-scale research to pilot plant and commercial manufacturing.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-5-Oxa-2-Azaspiro[3.5]Nonane-2-Carboxylate
CAS No.	1779396-21-2
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	8-Hydroxy-5-oxa-2-azaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 8-hydroxy-5-oxa-2-azaspiro[3.5]nonane-2-carboxylate; 2-Azaspiro[3.5]nonane-2-carboxylic acid, 8-hydroxy-5-oxa-, 1,1-dimethylethyl ester; 1779396-21-2; Spirocyclic oxazolidinone intermediate; Boc-protected spirocyclic amino alcohol.
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Hydroxy-5-Oxa-2-Azaspiro[3.5]Nonane-2-Carboxylate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.