Description

6-Oxaspiro[2.5]Octan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic oxetane-amine structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting complex molecular architectures. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing spirocyclic scaffolds in drug discovery, particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to modulate the physicochemical properties of candidate molecules.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for new APIs.
• Academic Research: Employed in synthetic organic chemistry studies focused on the reactivity and applications of strained heterocycles like oxetanes.
• Custom Synthesis: Basis for the preparation of specialized derivatives, reference standards, or labeled compounds for biological testing.

Basic Information

Product Name	6-Oxaspiro[2.5]Octan-1-Amine Hydrochloride
CAS No.	1779133-13-9
Molecular Formula	C7H14ClNO
Molecular Weight	163.65 g/mol
Synonyms	1-Amino-6-oxaspiro[2.5]octane hydrochloride; 6-Oxaspiro[2.5]octan-1-amine HCl; Spiro[oxetane-3,1'-cyclopentane]-1'-amine hydrochloride; 1-Azaspiro[2.5]octan-6-ol, hydrochloride (tautomeric form); Oxetane-spiro-cyclopentylamine hydrochloride; 1'-Aminospiro[cyclopentane-1,3'-oxetane] hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Oxaspiro[2.5]Octan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.