Description

tert-Butyl 2-Cyclopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic triaza scaffold. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, especially within oncology and central nervous system (CNS) research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic and heterocyclic components.
• Proteolysis Targeting Chimera (PROTAC) Development: A valuable scaffold for constructing E3 ligase ligands in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Employed in the creation of potent and selective kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating novel biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up under cGMP conditions.

Basic Information

Item	Details
Product Name	tert-Butyl 2-Cyclopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate
CAS No.	1779126-43-0
Molecular Formula	C16H24N4O3
Molecular Weight	320.39 g/mol
Synonyms	1,3,8-Triazaspiro[4.5]dec-1-ene-8-carboxylic acid, 2-cyclopropyl-4-oxo-, 1,1-dimethylethyl ester; tert-Butyl 2-cyclopropyl-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate; 8-Boc-2-cyclopropyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one; 2-Cyclopropyl-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylic acid tert-butyl ester; Spirocyclic triaza intermediate CAS 1779126-43-0
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-Cyclopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization using HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.