Description

tert-Butyl 2-(2-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and triaza scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and oncological pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to build sophisticated molecular libraries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The triazaspiro[4.5]decane core is a privileged structure in the design of enzyme inhibitors.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and target validation.
• Custom Synthesis: Starting material for the contract manufacturing of specialized fine chemicals and advanced intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organofluorine chemistry.

Basic Information

Item	Detail
Product Name	tert-Butyl 2-(2-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate
CAS No.	1774896-08-0
Molecular Formula	C18H22FN3O3
Molecular Weight	347.39 g/mol
Synonyms	8-Boc-2-(2-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one; tert-Butyl 2-(2-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate; 1,3,8-Triazaspiro[4.5]dec-1-ene-8-carboxylic acid, 2-(2-fluorophenyl)-4-oxo-, 1,1-dimethylethyl ester; BOC-protected 2-(2-fluorophenyl)triazaspirodecenone; 1774896-08-0; FC-AD-147/42007036; AK-918/40438007
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(2-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.