Description

2-Cyclopropyl-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1774895-85-0. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is essential for research and development organizations, contract manufacturing organizations (CMOs), and pharmaceutical companies focused on innovative drug discovery programs.

Application

This specialized spirocyclic compound serves as a versatile intermediate in advanced chemical synthesis. Key application areas include:

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: Serves as a starting material for the contract synthesis of proprietary compounds and complex molecular entities.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	2-Cyclopropyl-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Hydrochloride
CAS No.	1774895-85-0
Molecular Formula	C12H19ClN4O
Molecular Weight	270.76 g/mol
Synonyms	2-Cyclopropyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one hydrochloride; 1,3,8-Triazaspiro[4.5]dec-1-ene-4-one, 2-cyclopropyl-, hydrochloride; 2-Cyclopropyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one HCl; Spiro[4.5]decane-4-one, 2-cyclopropyl-1,3,8-triaza-, hydrochloride; CAS 1774895-85-0
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.