Description

Ethyl (1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate is a high-value, stereochemically defined fluorinated building block essential for advanced organic synthesis. This compound matters because its unique structure, featuring both fluorine and hydroxyl groups on a cyclohexane ring, enables the precise modulation of molecular properties in target molecules, such as metabolic stability and bioavailability. It is primarily needed by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the fluorine atom enhances biological activity and environmental persistence.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring the effects of fluorination on conformational and physicochemical properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and fluorination.

Basic Information

Product Name	Ethyl (1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate
CAS No.	1715034-50-6
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	(1R,3S,4S)-Ethyl 3-Fluoro-4-hydroxycyclohexanecarboxylate; Ethyl trans-3-Fluoro-4-hydroxycyclohexanecarboxylate; 3-Fluoro-4-hydroxycyclohexanecarboxylic Acid Ethyl Ester; (1R,3S,4S)-3-Fluoro-4-hydroxycyclohexane-1-carboxylic Acid Ethyl Ester; 1715034-50-6; Fluorinated Cyclohexane Ester; Chiral Fluorinated Building Block
EINECS	Contact for details

Quality Control

Our Ethyl (1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.