Description

Propargyl-PEG3-phosphonic acid is a specialized bifunctional linker molecule featuring a terminal alkyne group and a phosphonic acid moiety, connected by a triethylene glycol spacer. This unique structure makes it a critical reagent for bioconjugation and surface modification, enabling robust and stable linkages under mild conditions. It is essential for researchers and manufacturers in pharmaceutical development, materials science, and diagnostic assay production who require precise and reliable cross-linking strategies.

Application

• Bioconjugation Reagent: Used for site-specific labeling of biomolecules (proteins, peptides, oligonucleotides) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Surface Functionalization: Enables the covalent attachment of biomolecules or polymers to metal oxide surfaces (e.g., titanium, tantalum, silica) through its phosphonic acid group for biosensor and implant coating applications.
• Pharmaceutical Linker: Serves as a building block in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Polymer Modification: Acts as a functional monomer or chain-end modifier to introduce clickable alkyne handles into polymeric materials for further derivatization.
• Diagnostic Probe Synthesis: Facilitates the creation of labeled probes for fluorescence in situ hybridization (FISH) and other imaging techniques.
• Material Science Research: Employed in creating self-assembled monolayers (SAMs) on oxide surfaces for studying interfacial properties and cell-material interactions.

Basic Information

Item	Detail
Product Name	Propargyl-PEG3-phosphonic Acid
CAS No.	1714139-62-4
Molecular Formula	C9H17NO6P
Molecular Weight	266.21 g/mol
Synonyms	2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethylphosphonic Acid; Propargyl-Oligoethylene glycol-phosphonic Acid; Propargyl-PEG3-Phosphonic Acid; 3-(2-{2-[2-(Prop-2-yn-1-yloxy)ethoxy]ethoxy}ethoxy)propane-1-phosphonic Acid; Alkyne-PEG3-Phosphonic Acid; Click Chemistry Phosphonic Acid Linker; Propargyl Triethylene Glycol Phosphonate (acid form)
EINECS	Contact for details

Quality Control

Every batch of Propargyl-PEG3-phosphonic acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR (¹H and ³¹P), and mass spectrometry analysis. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.