Description

tert-Butyl 2-Isopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and heterocyclic architecture. This compound is of significant value in modern medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly within oncology and central nervous system (CNS) research.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for constructing complex molecular frameworks in drug discovery and development pipelines.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the research and synthesis of novel PROTAC molecules, a promising therapeutic modality for targeted protein degradation.
• Kinase Inhibitor Research: Employed as a precursor in the synthesis of potential kinase inhibitors for oncology and inflammatory disease applications.
• Medicinal Chemistry & Lead Optimization: Provides a versatile scaffold for structure-activity relationship (SAR) studies and the optimization of drug-like properties.
• Contract Research Organization (CRO) & Contract Development and Manufacturing Organization (CDMO) Services: Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in synthetic organic chemistry and new therapeutic mechanisms.

Basic Information

Product Name	tert-Butyl 2-Isopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate
CAS No.	1713162-87-8
Molecular Formula	C16H27N3O3
Molecular Weight	309.41 g/mol
Synonyms	8-Boc-2-isopropyl-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene; tert-Butyl 2-isopropyl-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate; 1,3,8-Triazaspiro[4.5]dec-1-ene-8-carboxylic acid, 2-(1-methylethyl)-4-oxo-, 1,1-dimethylethyl ester; Boc-Protected Spirocyclic Triazine Intermediate; Spiro[4.5]decane Triazine Derivative; CAS 1713162-87-8; 2-Isopropyl-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Isopropyl-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-Ene-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.