Description

tert-Butyl 4-Chloro-2-Oxo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylat is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily needed by pharmaceutical companies and contract research organizations (CROs) focused on developing new therapeutic agents, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting protein-protein interactions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its complex, three-dimensional spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of novel bifunctional degraders.
• Kinase Inhibitor Synthesis: Intermediate for the development of selective kinase inhibitors, leveraging the indole and piperidine motifs.
• Chemical Biology Probes: Used to create tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects requiring gram to kilogram quantities under cGMP or non-GMP conditions.

Basic Information

Product Name	tert-Butyl 4-Chloro-2-Oxo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylat
CAS No.	1707602-35-4
Molecular Formula	C17H21ClN2O3
Molecular Weight	336.81 g/mol
Synonyms	1'-Boc-4-chloro-2-oxospiro[indoline-3,4'-piperidine]; 4-Chloro-1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 1'-tert-Butoxycarbonyl-4-chloro-2-oxospiro[indoline-3,4'-piperidine]; 4-Chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester; 1707602-35-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-2-Oxo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylat is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard material meets typical research-grade specifications, and we can support development under cGMP guidelines for advanced clinical-stage requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.