Description

7-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry research and development. This compound is valued for its role as a key building block in the synthesis of novel bioactive molecules, particularly those targeting central nervous system (CNS) disorders. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new molecules with improved efficacy and safety profiles.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• API Development: Serves as a building block in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly within the spirocyclic and heterocyclic chemical space.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing outsourced R&D and production services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and pharmacology.

Basic Information

Product Name	7-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride
CAS No.	1707602-26-3
Molecular Formula	C12H12BrN2O • HCl
Molecular Weight	331.60 g/mol (Free base: 295.14 g/mol)
Synonyms	7-Bromospiro[indole-3,4'-piperidin]-2(1H)-one hydrochloride; 7-Bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-2-one HCl; 7-Bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine] hydrochloride; Spiro[indole-3,4'-piperidine]-2-one, 7-bromo-1,2-dihydro-, hydrochloride; 1707602-26-3; 7-Bromo-1H-spiro[indole-3,4'-piperidine]-2(3H)-one hydrochloride
EINECS	Contact for details

Quality Control

Our 7-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, assay, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.