Description

tert-Butyl 6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate CAS NO 1707369-75-2 is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Chemical Biology Probes: Utilized to develop tool compounds for studying biological pathways and target validation.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Employed in university and institutional labs for pioneering synthetic methodology and novel heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1707369-75-2
Molecular Formula	C17H21BrN2O2
Molecular Weight	365.27 g/mol
Synonyms	6-Bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-6-bromo-1,2-dihydrospiro[indole-3,4'-piperidine]; tert-Butyl 6-bromo-2,3-dihydro-1H-spiro[indole-3,4'-piperidine]-1'-carboxylate; 6-Bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 6-bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 6-Bromospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-6-bromo-spiro[indoline-3,4'-piperidine]; 1707369-75-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for advanced intermediates to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.