Description

2-Methyl-6-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with significant utility in modern drug discovery and development. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders. It is primarily sought by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of new APIs.
• Biochemical Research: Employed as a tool compound in pharmacological assays and receptor binding studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2-Methyl-6-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride
CAS No.	1707367-81-4
Molecular Formula	C11H17N2O·2HCl
Molecular Weight	265.19 g/mol (Free base: 193.27 g/mol)
Synonyms	2-Methyl-6-(3-pyrrolidinyloxy)pyridine dihydrochloride; 6-(Pyrrolidin-3-yloxy)-2-picoline dihydrochloride; 2-Methyl-6-(pyrrolidin-3-yloxy)pyridine hydrochloride (1:2); 2-Methyl-6-[(3R)-pyrrolidin-3-yloxy]pyridine dihydrochloride (for enantiopure form); 1707367-81-4; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our 2-Methyl-6-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.