Description

tert-Butyl 3-Bromo-2-oxopiperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a reactive bromo and keto functional group on a piperidine scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the efficient synthesis of complex nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of piperidine-based drug candidates in therapeutic areas such as neurology and oncology.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce halogen and carbonyl handles for further derivatization.
• API Synthesis: Serves as a precursor in multi-step synthetic routes for the production of complex target molecules.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and molecular probes for studying biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl 3-Bromo-2-oxopiperidine-1-carboxylate
CAS No.	1707358-29-9
Molecular Formula	C10H16BrNO3
Molecular Weight	278.14 g/mol
Synonyms	1-Boc-3-bromo-2-piperidinone; 3-Bromo-1-(tert-butoxycarbonyl)-2-piperidinone; tert-Butyl 3-bromo-2-oxo-1-piperidinecarboxylate; 3-Bromo-2-oxopiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-bromo-2-piperidinone; 3-Bromo-2-piperidinone-1-carboxylic acid tert-butyl ester; Boc-3-bromo-2-piperidinone
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-2-oxopiperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.