Description

(3S,4S)-4-Azidotetrahydro-2H-Pyran-3-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its unique azido and amine functional groups, which are versatile handles for click chemistry and further derivatization, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in medicinal chemistry, particularly for the development of novel therapeutics, including antiviral agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for antiviral and antibacterial compounds.
• Medicinal Chemistry: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its reactive azide group for bioorthogonal conjugation.
• Click Chemistry Reagent: Serves as a vital component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages in polymers, bioconjugates, and chemical probes.
• Organic Synthesis Building Block: Employed in the asymmetric synthesis of complex natural products and heterocyclic compounds containing nitrogen and oxygen.
• Bioconjugation: Facilitates the labeling and modification of biomolecules such as proteins, peptides, and oligonucleotides for diagnostic and therapeutic applications.
• Chemical Biology Research: Utilized in the development of activity-based probes and chemical tools to study biological pathways and enzyme functions.

Basic Information

Product Name	(3S,4S)-4-Azidotetrahydro-2H-Pyran-3-Amine Hydrochloride
CAS No.	1707289-89-1
Molecular Formula	C5H11N4O•HCl
Molecular Weight	178.63 g/mol
Synonyms	(3S,4S)-4-Azidotetrahydro-2H-pyran-3-amine hydrochloride; (3S,4S)-4-Azidotetrahydropyran-3-amine HCl; 4-Azido-3-aminotetrahydropyran hydrochloride (stereospecific); 3-Amino-4-azidotetrahydropyran hydrochloride; Tetrahydro-2H-pyran-3-amine, 4-azido-, hydrochloride, (3S,4S)-; Azidotetrahydropyranylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (3S,4S)-4-Azidotetrahydro-2H-Pyran-3-Amine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.