Description

Propanoic Acid, 3,3'-[[2-(3-Azidopropyl)-2-Methyl-1,3-Dioxan-5-Ylidene]Bis(Methylenesulfinyl)]Bis-, 1,1'-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is a sophisticated heterobifunctional crosslinking agent designed for advanced bioconjugation and materials science applications. Its molecular architecture, featuring an activated NHS ester and a photo-reactive azide group, enables efficient and selective coupling between amine-containing biomolecules and alkyne-modified surfaces or polymers under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of functionalized biomaterials, where precise and stable covalent linkages are required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: For site-specific coupling of cytotoxic drugs, fluorophores, or other payloads to monoclonal antibodies and proteins.
• Proteomics and Biomarker Discovery: As a crosslinker in activity-based protein profiling (ABPP) and chemical proteomics to capture and identify enzyme targets.
• Surface Functionalization and Biochip Fabrication: To immobilize peptides, proteins, or oligonucleotides onto sensor chips, microarray slides, or nanoparticles for diagnostic and biosensing applications.
• Polymer Chemistry and Hydrogel Synthesis: As a key monomer or crosslinking unit for creating smart, stimuli-responsive hydrogels and biocompatible polymer networks.
• Click Chemistry Reagent: Utilized in copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for labeling biomolecules in live cells.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs.

Basic Information

Product Name	Propanoic Acid, 3,3'-[[2-(3-Azidopropyl)-2-Methyl-1,3-Dioxan-5-Ylidene]Bis(Methylenesulfinyl)]Bis-, 1,1'-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	1704097-02-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3,3'-[[2-(3-Azidopropyl)-2-Methyl-1,3-Dioxan-5-Ylidene]Bis(Methylenesulfinyl)]Dipropionic Acid Bis(N-succinimidyl) Ester; NHS-Azide Heterobifunctional Crosslinker; Azido-PEG4-NHS Ester (structural analog); SDA (Sulfinyl-Dioxane-Azide) Crosslinker; Photo-reactive NHS Ester; Bifunctional Click Chemistry Reagent; CAS 1704097-02-8; Azide-NHS Linker
EINECS	Contact for details

Quality Control

Our Propanoic Acid, 3,3'-[[2-(3-Azidopropyl)-2-Methyl-1,3-Dioxan-5-Ylidene]Bis(Methylenesulfinyl)]Bis-, 1,1'-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.