Description

L-Serine, 2-Methyl-, 1,1-Dimethylethyl Ester is a protected amino acid derivative, specifically a tert-butyl ester of a methyl-substituted serine. This compound is a crucial chiral building block in organic synthesis, offering enhanced stability and solubility for complex peptide coupling and medicinal chemistry applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, peptide-based drugs, and advanced biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce modified serine residues, influencing peptide stability and bioactivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic targets.
• Bioconjugation: Acts as a linker or modified amino acid in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology: Utilized as a probe or labeled compound in biochemical assays and metabolic pathway studies.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, bioactive agrochemicals.

Basic Information

Product Name	L-Serine, 2-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	1702791-53-4
Molecular Formula	C8H17NO3
Molecular Weight	175.23 g/mol
Synonyms	(2S)-2-Amino-3-hydroxy-2-methylbutanoic acid tert-butyl ester; tert-Butyl (2S)-2-amino-3-hydroxy-2-methylbutanoate; O-tert-Butyl-L-threonine; L-2-Methylserine tert-butyl ester; (S)-2-Amino-3-hydroxy-2-methylbutyric acid tert-butyl ester; 1,1-Dimethylethyl (2S)-2-amino-3-hydroxy-2-methylbutanoate
EINECS	Contact for details

Quality Control

Our L-Serine, 2-Methyl-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.