Description

Methyl 2-Amino-4-Bromo-5-Chloro-3-Fluorobenzoate is a high-purity, multi-halogenated benzoate derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring amino, bromo, chloro, and fluoro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Serves as a precursor in the development of next-generation herbicides, fungicides, and insecticides, leveraging the halogen pattern for bioactivity.
• Material Science: Used in the research and production of specialty polymers, liquid crystals, and organic electronic materials where halogenated aromatic cores are required.
• Chemical Synthesis: A versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling rapid diversification of molecular scaffolds.
• Dye & Pigment Industry: Intermediate for the synthesis of complex halogenated dyes and pigments, offering enhanced lightfastness and color properties.

Basic Information

Product Name	Methyl 2-Amino-4-Bromo-5-Chloro-3-Fluorobenzoate
CAS No.	1698028-15-7
Molecular Formula	C8H6BrClFNO2
Molecular Weight	282.49 g/mol
Synonyms	Methyl 2-amino-4-bromo-5-chloro-3-fluorobenzoate; Benzoic acid, 2-amino-4-bromo-5-chloro-3-fluoro-, methyl ester; 2-Amino-4-bromo-5-chloro-3-fluorobenzoic acid methyl ester; Methyl 2-amino-4-bromo-5-chloro-3-fluorobenzoate; Methyl 4-bromo-5-chloro-2-amino-3-fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-Bromo-5-Chloro-3-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.