Description

2-Amino-4-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethyl and amino substituents. This compound is essential for the synthesis of advanced molecules, offering significant advantages in modulating the biological activity, metabolic stability, and lipophilicity of target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, anti-cancer agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups and potential for further functionalization.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, tags, and activity-based probes (ABPs) for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated compounds.

Basic Information

Product Name	2-Amino-4-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester
CAS No.	1698027-36-9
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.61 g/mol
Synonyms	Methyl 2-Amino-4-chloro-5-(trifluoromethyl)benzoate; Benzoic acid, 2-amino-4-chloro-5-(trifluoromethyl)-, methyl ester; 2-Amino-4-chloro-α,α,α-trifluoro-m-toluic acid methyl ester; Methyl 2-amino-4-chloro-α,α,α-trifluoro-m-toluate; 4-Chloro-2-amino-5-trifluoromethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Amino-4-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for solvent residue analysis. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our commitment to consistent high purity and reliable supply supports critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.