Description

1-[Cyclopropyl(9H-Fluoren-9-Ylmethoxycarbonyl)Amino]Cyclobutane-1-Carboxylic Acid is a specialized, high-purity building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex chemical processes. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) as a protected amino acid derivative, particularly for introducing constrained, cyclobutane-based structures.
• Protecting Group Strategy: The 9-Fluorenylmethoxycarbonyl (Fmoc) group is a standard, acid-labile protecting group for amines, making this compound essential for sequential peptide assembly.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by incorporating cyclopropyl and cyclobutane motifs, which can influence a molecule's conformation and metabolic stability.
• Bioconjugation: Serves as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugation platforms.
• Custom Synthesis: Supplied to contract research organizations (CROs) and contract development and manufacturing organizations (CDMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	1-[Cyclopropyl(9H-Fluoren-9-Ylmethoxycarbonyl)Amino]Cyclobutane-1-Carboxylic Acid
CAS No.	1697367-12-6
Molecular Formula	C27H27NO4
Molecular Weight	429.51 g/mol
Synonyms	1-[(Cyclopropyl{[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid; Fmoc-Cyclobutyl(Cyclopropyl)-Gly-OH; 1-[(N-Fmoc-N-cyclopropyl)amino]cyclobutane-1-carboxylic acid; N-cyclopropyl-N-(Fmoc)cyclobutylglycine; Cyclobutane-1-carboxylic acid, 1-[cyclopropyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-; Fmoc-Cpg(Cyclopropyl)-OH; (1-Carboxycyclobutyl)(cyclopropyl)carbamic acid 9H-fluoren-9-ylmethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-[Cyclopropyl(9H-Fluoren-9-Ylmethoxycarbonyl)Amino]Cyclobutane-1-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider storage at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.