Description

3-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex heterocyclic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester precursor for palladium-catalyzed C-C bond formation in complex molecule synthesis.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those containing functionalized pyrazole cores.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with pyrazole motifs.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Useful for constructing bifunctional molecules in targeted protein degradation research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	3-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Pyrazole
CAS No.	1690341-57-1
Molecular Formula	C16H31BN2O3Si
Molecular Weight	338.33 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; 1H-Pyrazole, 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-; SEM-Protected 3-Methyl-4-Boronopyrazole Pinacol Ester; 4-Borono-3-methyl-1H-pyrazole-1-ethanol, 2-(trimethylsilyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including NMR (1H, 13C, 11B), HPLC, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.