Description

Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)-, cis- is a high-value, stereochemically defined fluorinated building block. This compound is critical for medicinal chemistry and advanced material science due to the unique combination of the strained cyclobutane ring and the metabolically stable trifluoromethyl group. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for developing new drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides with enhanced activity and environmental profile.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and other specialty materials requiring specific steric and electronic properties.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis to explore novel chemical space.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or a template in stereoselective synthesis routes.
• Fluorine Chemistry: An important reagent for introducing the CF3 group in a complex, conformationally restricted molecular framework.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)-, cis-
CAS No.	1690177-86-6
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	cis-3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic Acid; (1r,3s)-3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic Acid; (1R,3S)-3-(Trifluoromethyl)cyclobutane-1,3-dicarboxylic Acid 1-Methyl Ester (related derivative); 3-Hydroxy-3-trifluoromethylcyclobutanecarboxylic Acid; FC-COOH (Fluorinated Cyclobutane Carboxylic Acid) building block; Trifluoromethyl Cyclobutanol Carboxylic Acid; cis-3-(Trifluoromethyl)cyclobutane-1,3-diol-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)-, cis- adheres to stringent quality protocols suitable for research and cGMP-grade applications. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and stereochemical purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, temperatures of 2-8°C are recommended to maintain stability. The compound may be hygroscopic (moisture-sensitive); handle and store under inert atmosphere (e.g., nitrogen or argon) for optimal preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.