Description

Bis(2,5-Dioxopyrrolidin-1-Yl) (Disulfanediylbis(Ethane-2,1-Diyl)) Dicarbonate is a specialized heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive disulfide group. This compound is engineered for the controlled, reversible conjugation of biomolecules, enabling the formation of cleavable linkages under reducing conditions. It is a critical tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and advanced polymer synthesis, where precise and reversible crosslinking is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via a cleavable disulfide bridge.
• Protein and Peptide Modification: Site-specific conjugation of peptides, proteins, or enzymes to other molecules, surfaces, or carriers.
• Biomolecule Immobilization: Reversible tethering of proteins or nucleic acids to solid supports (e.g., sensor chips, chromatography resins) for assay development.
• Polymer Functionalization: Introducing reactive handles or cleavable crosslinks into synthetic polymers for smart material and drug delivery system design.
• Diagnostic Reagent Synthesis: Production of labeled probes and reagents for immunoassays and molecular diagnostics.
• Stimuli-Responsive Material Fabrication: Creating hydrogels or nanoparticles that degrade or release cargo in response to reducing environments.

Basic Information

Product Name	Bis(2,5-Dioxopyrrolidin-1-Yl) (Disulfanediylbis(Ethane-2,1-Diyl)) Dicarbonate
CAS No.	1688598-83-5
Molecular Formula	C16H18N2O10S2
Molecular Weight	462.45 g/mol
Synonyms	NHS-SS-NHS; NHS-Disulfide-NHS; Disuccinimidyl 3,3'-dithiodipropionate (DTSSP) analog; 1,1'-[Dithiobis(ethane-2,1-diylcarbonyloxy)]bis(2,5-pyrrolidinedione); Bis(N-succinimidyl) 3,3'-dithiodipropionate; Heterobifunctional NHS-SS crosslinker; Disulfide-containing NHS ester; DSC-SS-DSC; S-SANHS
EINECS	Contact for details

Quality Control

Our Bis(2,5-Dioxopyrrolidin-1-Yl) (Disulfanediylbis(Ethane-2,1-Diyl)) Dicarbonate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for functional group verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.