Description

Azido-PEG9-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group at one terminus and a carboxylic acid at the other. This bifunctionality is critical for creating stable, well-defined conjugates in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors for constructing antibody-drug conjugates (ADCs), peptide modifications, and functionalizing surfaces or nanoparticles.

Application

• Bioconjugation and ADC Development: The azide group enables copper-free click chemistry (e.g., strain-promoted alkyne-azide cycloaddition, SPAAC) for site-specific labeling of biomolecules, while the carboxylic acid allows for amide coupling to amines, facilitating the creation of stable linker-payload systems.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer to peptides, proteins, or small molecules, improving solubility, reducing immunogenicity, and extending circulatory half-life.
• Surface Functionalization: The acid group can be used to anchor the linker to amine-coated surfaces (e.g., chips, beads, nanoparticles), presenting azide groups for subsequent click chemistry-based immobilization of alkyne-tagged ligands or probes.
• Crosslinking Agent: Serves as a versatile heterobifunctional crosslinker to bridge molecules containing alkyne and amine functional groups under mild, aqueous-compatible conditions.
• Polymer and Materials Chemistry: A key building block for synthesizing functionalized polymers, hydrogels, and smart materials with tailored biological or physical properties.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging agents and diagnostic probes by linking targeting molecules (via the acid) to reporter molecules (via the azide).

Basic Information

Product Name	Azido-PEG9-acid
CAS No.	1670249-37-2
Molecular Formula	C₂₂H₄₃N₃O₁₁
Molecular Weight	549.6 g/mol
Synonyms	Azido-PEG9-COOH; 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-oic acid; α-Azido-ω-carboxy nonaethylene glycol; N3-PEG9-acid; Azido-PEG9-acid; Azido-PEG9-COOH; PEG9-azide-acid; 2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
EINECS	Contact for details

Quality Control

Our Azido-PEG9-acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (¹H NMR, FT-IR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccate upon opening and minimize exposure to ambient atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.