Description

(S,E)-7-(2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)-1H-Pyrrol-1-Yl)-5-Hydroxyhept-2-Enoic Acid Calcium(Ii) is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant pharmacological research value. This compound is a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting cyclooxygenase (COX) inhibition pathways. It is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers developing next-generation anti-inflammatory and analgesic therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor for novel NSAID and COX-2 inhibitor APIs.
• Research & Development: Critical material for medicinal chemistry programs focused on inflammation, pain, and fever pathways.
• Process Chemistry: Used in scale-up and optimization studies for new drug manufacturing processes.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Employed in university and institutional studies investigating prostaglandin synthesis and related biochemical mechanisms.
• Custom Synthesis: Starting point for the development of proprietary drug candidates and patent-protected chemical entities.

Basic Information

Product Name	(S,E)-7-(2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)-1H-Pyrrol-1-Yl)-5-Hydroxyhept-2-Enoic Acid Calcium(Ii)
CAS No.	1659317-57-3
Molecular Formula	C39H37CaFNO5
Molecular Weight	649.79 g/mol
Synonyms	Calcium (2E,5S)-7-[2-(4-fluorophenyl)-5-(propan-2-yl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-5-hydroxyhept-2-enoate; (S,E)-Calcium 7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxyhept-2-enoate; 1659317-57-3; Calcium NSAID Intermediate; COX Inhibitor Intermediate; Fluorophenyl Pyrrole Carboxamide Derivative Calcium Salt
EINECS	Contact for details

Quality Control

Our (S,E)-7-(2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)-1H-Pyrrol-1-Yl)-5-Hydroxyhept-2-Enoic Acid Calcium(Ii) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material meeting custom specification requirements for advanced R&D and pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.